Negative frequency-dependent selection on MHC uncovered by an emergent parasite
High polymorphism of major histocompatibility complex (MHC) genes that encode proteins crucial for adaptive immunity of vertebrates have been long hypothesized to be maintained by negative frequency-dependent selection resulting from adaptation of parasites to common MHC types, but supporting evidence is scarce. In our new paper in Molecular Ecology (Migalska et al. 2022, http://doi.org/10.1111/mec.16486) we find [...]